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Moreover, as we ended up intrigued in pinpointing candidate tumour-distinct mutations, we disregarded all mutations that were also detected in the HapMap samples, as an approximate normalisation for very likely germline variation. As a further amount of stringency we also regarded as copy number modifications across the Capan-one genome, as described by the aCGH analysis. This is especially relate
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Electrode was designed to be minimally invasive and only enter the descending basal turn of the scala tympani between 190 and 200 degrees. This short intracochlear electrode had a reduced diameter of 0.2 X 0.4 mm as compared to standard-length cochlear implants. Six electrodes (channels) are located in the distal 5 mm of the electrode. The device was placed through a 0.5?.6 mm cochleostomy located
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Primarily based on our encounter, the use of location-certain filters for sequencing depth facilitates far more trustworthy variant identification. Plainly, heterozygous variants called in one duplicate locations are likely to be false , and somewhere else, the variety of reads bearing the variant allele can fluctuate in a different way depending on the copy quantity position. Hence self-confidenc
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